Causes - Bp Harmony

Causes

Bipolar disorder is a mental health condition characterized by extreme fluctuations in mood, energy, and activity levels. These mood swings range from periods of intense excitement or euphoria, known as mania or hypomania, to episodes of deep depression. The disorder’s complexity makes it challenging to diagnose and manage, but understanding its symptoms and causes is essential for effective treatment and better long-term outcomes.

Causes Of Bipolar Disorder

With almost 3% of the American population experiencing symptoms of Bipolar Disorder, it has become imperative to understand the causes of the illness, regardless of the type. This helps answering some vital questions, such as:

Do I have bipolar disorder?
What is the cause of bipolar?
Is bipolar genetic?

When it comes to bipolar disorder, or more commonly known as bpd, several factors come into play. From genetics to environmental factors, the cause can vary from patient to patient. This is why experts are unable to underline one single cause that affects 40 million people worldwide. This page takes a rundown of the commonly accepted causes and how they can lead to a person developing bipolar disorder in people.

Is Bipolar Disorder Genetic?

Research shows that Bipolar Disorder, particularly the more severe form known as Bipolar I Disorder, is strongly influenced by genetic factors. Although the disorder is complex and likely involves multiple genes, genetic inheritance plays a significant role in its development. Studies have estimated that genetics account for approximately 60 to 80% of the risk for developing Bipolar Disorder. This means that individuals with a family history of Bipolar Disorder are at a much higher risk of developing the condition themselves. However, it’s important to note that while genetics are a major factor, environmental and lifestyle factors also contribute to the onset and course of the disorder.

When it comes to genetics, there are a lot more factors to consider:

1. Heritability

As discussed above, this mental illness has a tendency of running in families. A first-degree relative with bpd has a significantly higher chance of developing the disorder than that of the general population. With such a high heritability, this makes bipolar disorder one of the most heritable psychiatric conditions.

2. Specific Gene And Variants

While no single gene causes bipolar disorder, researchers have identified several genes that may contribute to the condition. These genes are involved in various biological processes, including neurotransmitter regulation (like serotonin and dopamine), brain cell communication, and circadian rhythms (which regulate sleep-wake cycles).

Some of the genes that have been implicated include:

ANK3 and CACNA1C are involved in the regulation of ion channels in neurons, which are crucial for transmitting electrical signals in the brain.
ODZ4 is thought to play a role in neuronal development and synapse formation.
CLOCK and ARNTL are involved in regulating circadian rhythms, which are often disrupted in people with bipolar disorder.

3. Polygenic Risk

Bipolar disorder is considered polygenic, meaning it results from the combined effect of multiple genes, each contributing a small amount to the overall risk. Genome-wide association studies (GWAS) have identified several genetic variants that, when combined, can increase the likelihood of developing the disorder. However, these variants alone are not deterministic; they increase susceptibility but do not guarantee that a person will develop bipolar disorder.

Lifestyle & Environmental Causes Of Bipolar Disorder

When it comes to the environment and how it can cause bipolar disorder, there are three distinct variations of the cause:

Neurodevelopmental
Substances
Physical/Psychological Trauma

Neurodevelopmental Factors

Research has shown that maternal infections during pregnancy, particularly influenza, can increase the risk of neurodevelopmental disorders in the offspring, including bipolar disorder. The theory is that maternal infections can trigger an immune response that affects fetal brain development. This is thought to be due to the release of cytokines (inflammatory molecules) that cross the placenta and influence the developing brain.

There is also evidence that maternal infections during pregnancy, particularly influenza, can increase the risk of neurodevelopmental disorders in the offspring, including bipolar disorder. The theory is that maternal infections can trigger an immune response that affects fetal brain development. This is thought to be due to the release of cytokines (inflammatory molecules) that cross the placenta and influence the developing brain.

Substance Use

Cannabis, cocaine, opioids, and other drugs can also increase the risk of developing bipolar disorder. It is generally agreed that the risk is higher for people with a genetic predisposition to the disorder.

Cannabis can affect brain functioning, particularly in adolescents (age 10 to 19), and can increase the risk of psychiatric disorders. It affects the brain’s endocannabinoid system, which plays a role in mood regulation.
Cocaine and stimulants can induce manic-like symptoms, while withdrawal from these substances can trigger depressive episodes. Chronic use of these substances can lead to neurochemical imbalances that are associated with the mood swings characteristic of bipolar disorder.

Parental Loss

Experiencing the loss of a parent during childhood has been identified as a significant risk factor for developing bipolar disorder later in life. The loss can lead to profound psychological stress, affecting emotional regulation and increasing vulnerability to mood disorders.

Adversities and Abuse

Exposure to childhood adversities, including physical, emotional, or sexual abuse, is strongly associated with the development of various mental health conditions, including bipolar disorder. Such adversities can cause long-lasting changes in brain structure and function, particularly in areas involved in emotion regulation and stress response, such as the hippocampus and amygdala.

Brain Injury

Traumatic brain injury (TBI) has been linked to the development of mood disorders, including bipolar disorder. TBIs can cause structural damage to brain regions involved in mood regulation, such as the frontal lobes, leading to symptoms of mania, depression, or mixed episodes.

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Treatment Options

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Have More Questions?

How Long Can I Expect To Be In Therapy?

Therapy duration varies based on individual needs and the extent to which bipolar disorder has affected you. Some patients may benefit from short-term therapy, while others may require long- term support. Providing a specific timeframe is difficult, as treatment is tailored to each person.

Can Bipolar Disorder Be Managed Without Medication?

While medication is important in managing bipolar disorder, particularly in moderate to severe cases, there are complementary approaches that can also help. These include lifestyle changes, such as regular sleep and exercise, and mental health activities, such as therapy and stress management techniques.

Is There A BPHarmony Community?

Yes, BPHarmony offers a supportive community where you can connect with peers and others who are managing bipolar disorder. Our eCommunity

What Happens In A Therapy Session?

In our therapy sessions, patients are given a safe, confidential environment to share their thoughts, feelings, and experiences freely. The therapist listens, offers support, and helps guide you through your personal journey toward improved mental health and well-being, without any judgment.

Can I Continue Working While Receiving Treatment?

Yes, many individuals with bipolar disorder continue to work while receiving treatment. Effective management of the condition through therapy, medication, and lifestyle adjustments can help maintain stability and productivity in the workplace.

What Level Of Confidentiality Can I Expect?

At BPHarmony, we prioritize patient privacy and confidentiality. No information is shared without written consent from the patient, except in cases where there is a legal obligation to do so (such as situations involving risk of harm to the patient or others).